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The Human Upgrade: Biohacking for Longevity & PerformanceDr. Peter McCullough traces the spike protein's origins to 2015 gain-of-function research, explains why it can persist in the body for years after vaccination, and breaks down the science behind clearing it, the suppression of early COVID treatments, and what he'd change if he ran HHS.

Huberman LabDr. Alan Castel, PhD, is a professor of psychology at the University of California, Los Angeles (UCLA) and one of the world's foremost experts on human memory and cognitive aging. We discuss what science actually tells us about how to improve our learning ability and memory at any age. We also discuss how memory works, why all planning and imagination about the future is based on the past, false memories, and how to leverage curiosity, emotion, and self-testing retrieval practice to stamp in memories for the long term. We discuss what "superagers"—people who actually improve their cognitive capacity with age—do differently than everyone else. This episode is for anyone interested in the science of memory and tools to maintain and improve your memory across the lifespan. Thank you to our sponsors AG1: https://drinkag1.com/huberman Wealthfront*: https://wealthfront.com/huberman Helix Sleep: https://helixsleep.com/huberman Function: https://functionhealth.com/huberman Lingo: https://hellolingo.com/huberman Timestamps (00:00:00) Dr. Alan Castel (00:02:41) What Is Memory?, Reconstruction & Metacognition (00:04:49) Mnemonics, Remembering Names & Deeper Learning (00:08:22) The Penny & Apple Logo, Noticing vs Seeing, Learning Through Mistakes (00:10:43) Sponsors: Wealthfront & Helix (00:14:05) Neuroplasticity, Frustration, Curiosity & Mindset (00:17:42) Maintaining vs Learning New Things, Habits, Novelty & Emotional Memory (00:24:28) "Mental Photographs," Photo-Taking & Imagining the Future (00:29:28) Eyewitness Memory, the Ronald Cotton Case, Confidence vs Accuracy (00:35:07) Medium-Term & Prospective Memory, Hotel Fire Exits (00:40:28) Sponsor: AG1 (00:41:47) When Habits Turn Lethal, Aviation & Human Error (00:49:01) Why Memory Changes With Age; Alzheimer's & the Nun Study (00:52:34) Exercise & Hippocampal Volume, Falls & Balance (00:57:14) SuperAgers & Athletes; Regret, Balance & Being Driven (01:12:08) Sponsor: Function (01:13:45) Age Stereotypes, Subjective Age & Positive Age Beliefs (01:20:02) Goals & Plans, Scams; Anterior Midcingulate Cortex & SuperAgers (01:26:23) Culture, Resilience, Blue Zones & COVID (01:29:18) Adversity, the Positivity Effect & Intergenerational Learning (01:36:31) Sponsor: Lingo (01:38:00) Limitations & Purpose; Time, Family & Connection (01:44:58) Deliberately Building Memories; the ABCs of Successful Aging (01:51:02) Following Your Interests; Castel's Path & Older Adults (01:57:16) Mental Simulations, Curiosity Studies & Selectivity (02:01:19) Socioemotional Selectivity Theory; Steve Jobs & Lifespan (02:07:10) The Secret to Successful Aging; State vs Trait Curiosity (02:11:04) Scams & AI Voice Cloning (02:14:31) John Wooden, Wisdom, Love & Balance (02:17:41) Learning Through Mistakes; Does the Brain Get Better With Age? (02:25:00) Conclusion, Better With Age (02:26:00) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures *This experience may not be representative of other Wealthfront clients, and there is no guarantee of future performance or success. Experiences will vary. Andrew Huberman receives cash compensation from Wealthfront Brokerage for paid testimonials in his podcast, creating a conflict of interest. The Cash Account, which is not a deposit account, is offered by Wealthfront Brokerage LLC, member FINRA/SIPC. Wealthfront Brokerage is not a bank. The base APY is 3.30% on cash deposits as of January 30, 2026, is representative, subject to change, and requires no minimum. If eligible for the overall boosted rate of 4.05% offered in connection with this promo, your boosted rate is also subject to change if the base rate decreases during the 3 month promo period. Additional terms and conditions apply, which can be found on Wealthfront.com/Huberman. Funds in the Cash Account are swept to program banks, where it earns the variable APY. Same-day withdrawal or instant payment transfers may be limited by destination institutions, daily transaction caps, and by participating entities such as Wells Fargo, the RTP® Network, and FedNow® Service. New Cash Account deposits are subject to a 2-4 day holding period before becoming available for transfer. Investment advisory services are provided by Wealthfront Advisers LLC, an SEC-registered investment adviser. Securities investments: not bank deposits, bank-guaranteed or FDIC-insured, and may lose value. Learn more about your ad choices. Visit megaphone.fm/adchoices

The Peter Attia DriveView the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Gayatri Devi is a nationally recognized neurologist specializing in memory disorders, including Alzheimer's disease and related dementias. In this episode, Gayatri expl

The Human Upgrade: Biohacking for Longevity & PerformanceA Japanese village's daily breakfast of natto — rich in spermidine — triggers the Nobel Prize-winning cellular repair process of autophagy, reversing biological aging within 72 hours when combined with proper dosing, exercise, sleep, and diet.

Boundless LifeFull show notes: https://bengreenfieldlife.com/tectonpodcast In this episode with Dr. Mike Chesne, founder of Tecton Ketones™, you'll hear how a traumatic brain injury sustained in combat led him from Army Special Forces medic to ketone biochemist, and why he eventually built what he believes is a m

The Human Upgrade: Biohacking for Longevity & PerformanceJordan Harbinger joins Dave Asprey to share how he talked his way out of two kidnappings and breaks down the psychology-driven systems — calendar blocking, pain-point habit hacks, and relationship-building — he uses to stay productive and charming under pressure.

Boundless LifeFull show notes: https://bengreenfieldlife.com/502 In this solosode, you'll explore how to make peace with tinnitus after acoustic trauma, including the half dozen different root causes that can drive it and the specific supplements and technologies with research behind them, why cardiovascular fitn

The Human Upgrade: Biohacking for Longevity & PerformanceDave Asprey sits down with Dr. David Perlmutter to explore how brain inflammation and microglial dysfunction drive Alzheimer's, Parkinson's, and other neurodegenerative conditions — debunking the amyloid hypothesis along the way and examining emerging treatments like GLP-1 drugs, 40 hertz light therapy, and lifestyle interventions.

Huberman LabIn this Huberman Lab Essentials episode, I explain the biology and psychology of obsessive-compulsive disorder (OCD) and describe the neural circuitry behind repetitive "thought-action loops," including why compulsive actions actually strengthen the underlying obsessions rather than relieve them. I discuss the most effective treatments for OCD, including exposure-based cognitive behavioral therapy and SSRIs, and explain what the research shows about how these compare when used alone versus together. Finally, I describe a specific clinical protocol in which patients are guided into states of anxiety while learning to suppress compulsive responses, retraining the brain to break the OCD cycle. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman Timestamps (00:00:00) Obsessive-Compulsive Disorder (OCD) (00:00:11) OCD Prevalence & Impact, Obsessions & Compulsions (00:01:54) Categories: Checking, Repetition & Order; Contamination & Disgust (00:04:30) Anxiety, Fear (00:05:20) Sponsor: AG1 (00:06:40) Genetic Component of OCD (00:08:45) Neural Circuitry, Cortex, Striatum, Thalamus (00:10:16) Cortico-Striatal-Thalamic Loop; Imaging Studies, SSRIs (00:14:30) Sponsor: Eight Sleep (00:16:00) Diagnosis, Yale-Brown Obsessive Compulsive Scale (Y-BOCS) (00:18:00) Y-BOCS Categories, Identifying the Core Fear (00:19:30) Tool: Cognitive Behavioral Therapy (CBT) & Exposure Therapy (00:21:39) Anxiety Tolerance, Interrupting the Compulsion (00:23:23) Dr. Helen Blair Simpson, Ritual Prevention, Exposure Sessions (00:25:18) CBT vs Placebo vs SSRIs (00:26:30) Sponsor: Rorra (00:28:07) SSRIs & Serotonin System; Psychiatry & Causality (00:29:13) Cannabis, CBD & OCD; Transcranial Magnetic Stimulation (TMS) (00:31:48) Mindfulness Meditation, Holistic Treatments, NIH (00:33:40) Nutraceuticals, Inositol; Recap & Conclusion Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Tim Ferriss ShowGuy Oseary (@guyoseary) has been spotting talent before anyone else could see it for nearly four decades. Under his leadership at Maverick Records, Maverick sold more than 100 million albums. Guy has managed some of the biggest names in music, including Madonna, the Red Hot Chili Peppers, and U2, and was named Variety's Music Mogul of the Year in 2022. He executive produced Twilight, which became one of the most successful franchises in movie history, generating more than $3.5B. Guy was also an early investor in Vita Coco and co-founded A-Grade Investments and then Sound Ventures, now with nearly $2 billion under management. At A-Grade, his hits included Airbnb, Uber, and Spotify. Sound Ventures launched with less than $100M and has since had 86 exits and 26 IPOs.This episode is brought to you by:Momentous high-quality creatine for cognitive and muscular support: https://livemomentous.com/TimAG1 all-in-one nutritional supplement: DrinkAG1.com/TimTimestamps[00:00:00] Start.[00:02:01] How a West Hollywood balcony became a backstage pass.[00:03:51] A knife on Pico Boulevard and the snap decision to switch schools.[00:05:54] Faking a Beverly Hills address to get inside another world.[00:08:10] Wise Guy Records: a 15-year-old builds a portfolio out of nothing.[00:10:09] Guy's alternative terms when Bernie Brillstein offered $25,000.[00:11:34] The one moment that confirmed Guy was on the right path.[00:12:29] Freddy DeMann enters the picture and Guy proves himself with Ice-T's crew.[00:15:07] A desk at Maverick Records in exchange for no salary.[00:17:08] Chasing Hole and Rage Against the Machine — and losing both.[00:23:34] Candlebox in five minutes: seeing thousands in a room of 30.[00:24:11] Why "magic" beats everything else.[00:26:37] Signing Alanis off a single song, and stopping Muse mid-audition.[00:31:59] The real Alanis story: "Perfect," Joni Mitchell, and a 30-million-selling debut.[00:35:24] What Madonna taught Guy about thinking without walls.[00:38:50] From bands to Twilight: the power of a blank canvas.[00:45:30] How Guy got into investing, and the IdeaLab bet that wiped him out before the crash.[00:54:31] Why Guy is known as a great curator of people.[00:58:32] The three-month window that caught OpenAI and Anthropic.[01:06:07] AI music and the battle to ensure human musicians get paid.[01:09:30] How Spotify solved the problems Napster couldn't overcome.[01:14:50] SpaceX and Bitcoin: the ones that got away.[01:17:32] The rewards, rigors, and responsibilities of back-to-back touring.[01:21:44] Why Guy never stops to celebrate.[01:24:45] Splitting with Ashton Kutcher after 20 years.[01:27:30] Final thoughts on Guy's first podcast.*For show notes and past guests on The Tim Ferriss Show, please visit tim.blog/podcast.For deals from sponsors of The Tim Ferriss Show, please visit tim.blog/podcast-sponsorsSign up for Tim’s email newsletter (5-Bullet Friday) at tim.blog/friday.For transcripts of episodes, go to tim.blog/transcripts.Discover Tim’s books: tim.blog/books.Follow Tim:Twitter: twitter.com/tferriss Instagram: instagram.com/timferrissYouTube: youtube.com/timferrissFacebook: facebook.com/timferriss LinkedIn: linkedin.com/in/timferriss See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

The Human Upgrade: Biohacking for Longevity & PerformanceDiscover how a suppressed 1910 light therapy can restructure water inside your cells, boost mitochondrial energy, and reverse the damage caused by blue light and EMF exposure.

Huberman LabCesar Millan is a world-renowned dog behavior expert. We discuss how to adjust your energy and behavior to ensure your dog is calm and happy and always follows your lead. Cesar shares specific tools for: returning home to your dog each day, structuring their walks, and eliminating aggressive behaviors and anxiety. We discuss how to determine if your dog is front, middle, or back of the pack order—a hardwired feature that determines much of their needs and personality. And we explore how human-human interactions are based on balances in energy, too. Both dog owners and non-owners will gain extremely valuable insights and tools from this episode. Read the episode show notes at hubermanlab.com. Pre-order Protocols: https://protocolsbook.com Thank you to our sponsors AG1: https://drinkag1.com/huberman LMNT: https://drinklmnt.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Cesar Millan (00:03:54) Animal Instincts & Human Energy (00:06:31) Spirit, Sending Energy, Tool: Silence, Calm & Confident (00:16:48) Sponsors: LMNT & Joovv (00:19:30) Walking Dog; Pack Order, Tool: Picking a Puppy (00:26:44) Human & Dog Hierarchy; Greeting Dog, Tool: No Look, No Touch, No Speak (00:35:11) Calm Dog, Structured Walk, Tool: Weighted Backpack (00:44:17) Sponsor: AG1 & Eight Sleep (00:46:57) Exercise, Discipline & Affection (00:50:23) Relationship to Death, Spirituality (00:55:30) Human Energy, Rescue Dogs; Sensing Stress (01:01:36) Animal Intelligence, Cats; Being a Pack Leader (01:07:27) Calm Greeting, Humanizing Animals, Safety & Security, Anxious Dogs (01:12:41) Safety & Horses, Respecting Dogs; Human Selfishness, Pack Leader (01:21:31) Sponsor: Function (01:23:15) Human Leaders; Pack Order, Prioritizing Affection (01:32:17) Picking Human Partners, Good Pack Leaders (01:44:40) Dog & Testing Boundaries, Tool: Calm & Confidence (01:52:34) Cultivating Self-Awareness & Self-Discipline, Life Values (01:58:02) Clearing Mind, Tool: Cold Plunge (02:02:22) Honoring Pet Death, Celebration, Expressing Sadness (02:12:13) Understanding Energy, Dog Training & Hard Work (02:17:25) Dog Breeds & Exercise, Fostering Dogs; Spay & Neuter, Humping (02:23:50) Petting Dogs; Barking & Destructive Behaviors, Tools: Early Walks, Challenges (02:31:31) Spirit & Instincts, Training Humans; Acknowledgements (02:35:50) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Protocols Book, Sponsors, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices